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Purpose: To analyze the efficacy of fusional vergence therapy (FVT) in management of consecutive esotropia with diplopia after intermittent exotropia (IXT) surgery. The current study is carried on how FVT affects the duration of treatment, sensory fusion, and exotropic drift. Methods: This was a retrospective study for the medical record of 11 patients with consecutive esotropia after IXT surgery of 543 patients over the period of 5 year, with mean surgery age of 9.5 (range: 4–33 y). FVT was planned after minimum 6 weeks of surgery and was considered for maximum 24 weeks. Patients underwent a combination of office-based and home-based FVT. Successful outcome of therapy was considered where diplopia resolves in free space and achieves sensory fusion, stereopsis with no manifest deviation. Results: Record of 543 patients who had horizontal muscle surgery for IXT were identified and reviewed. Records of 11 patients who showed consecutive esotropia of 10 prism diopter (PD) or more with normal retinal correspondence, with or without diplopia complaint, after 6 week of surgery and had undergone vision therapy management were reviewed. A successful outcome of binocular single vision with good sensory and motor fusion with no manifest deviation or prism requirement was achieved with in the mean duration of 4.8 month of therapy. With a mean duration of 4 weeks of therapy, the mean angle of deviation reduced by 53% for distance (17 PD to 8 PD) and 27% for near (11 PD to 8 PD) and mean stereopsis improvement by 80% with 94% patients demonstrating sensory fusion on Bagolini test and 94% of patients having no symptoms of diplopia or squint. Conclusion: With nonsurgical management involving refractive error correction, FVT, and prism, consecutive esotropia was resolved in 74% cases. Management of consecutive esotropia with FVT can result in satisfactory sensory fusion and successful motor alignment.
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Information is a source of power and is important for individual growth and survival. Information about health and hygiene is crucial because it influences an individual’s quality of life. As far as health and hygiene practices are concerned, women play anactive role in getting information about these; hence there is a need to study their information needs regarding health and hygiene. After finding out the needs of women regarding these aspects, accordingly information can be made accessible to them. Keeping this into account, the present study was conducted in Ludhiana district of Punjab. Data was taken from 200 rural and urban women of 25-50 years, by the help of an interview schedule. Health and hygiene practices were studied under three categories as personal, food related and household health and hygiene practices. Information needs were studied on a three point continuum i.e. highly needed, somewhat needed and not needed. Results of the study showed that under personal health and hygiene practice, information on hair care and obesity was most needed. The most needed information regarding food related health and hygiene was on low cost nutritious recipes. The major information need reported by the respondents was related to control of insects and pests in case of household health and hygiene practices and majority of the respondents had low level of information need for all health and hygiene practices. Information needs of the women were positively related with their education and mass media exposure, whereas age was negatively correlated with the information needs of women. Consequently, there is a need to educate women regarding health and hygiene practices through effective communication methods, so that they can realize the importance and need for information on these topics
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Background: Gestational diabetes mellitus is defined as any glucose intolerance with the onset or first recognition during pregnancy. Objectives of this study were to diagnose cases of GDM by screening with DIPSI criteria at less than 28 weeks. And observation and comparison of maternal and perinatal outcome in women diagnosed of GDM in less than 20 weeks and at 24-28 weeks.Methods: This was the prospective analytical study conducted in the department of obstetrics and gynecology for one year in Muzaffarnagar medical college and Hospital. After history taking, clinical and obstetrics examination 1503 antenatal patients of less than 28 weeks were enrolled underwent screening with DIPSI criteria. Out of which 80 patients with abnormal OGTT of gestational age less than 20 weeks and 69 patients with abnormal OGTT of gestational age 24 -28 weeks.Results: In early diagnosed GDM group alive and healthy babies were slightly lower as compared with late diagnosed GDM group.Conclusions: The diagnosis of GDM gives us an opportunity in identifying individuals who will be benefitted by early therapeutic intervention with diet, exercise, and normalizing the weight to delay or prevent the onset of the disease.
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Metabolic syndrome is defined as a constellation of interconnected physiological, biochemical, clinical and metabolic factors that directly increase the risk of cardiovascular disease and Type 2 Diabetes Mellitus. It is a major and increasing public health problem and clinical challenge worldwide in the wake of urbanization, increasing obesity and sedentary life style. Metabolic syndrome defined by IDF (2006) as presence of Central obesity with any one of the 3 factor i.e., Raise Triglyceride, Reduced HDL, Raised BP or Raised FBS. It increases 5 fold risk of Type II DM and 2 fold risk of Cardio-vascular disease. Worldwide prevalence of Metabolic syndrome ranges from 10% to 84% depending upon the Region (Urban/Rural), Composition (sex, age, race, ethnicity) of Population. IDF estimates that 1/3rd of world Adult population have Metabolic Syndrome. According to NCEP - ATP III CRITERIA 2001 Metabolic syndrome varies from 8 to 43% in men and 7 to 56% in women around the world. Lifestyle modification remains the initial intervention of choice as majority of people have sedentary lifestyle high socio economic status high BMI and are overweight. So lifestyle modification combine with specific Ayurvedic therapies i.e., Palliative (Shaman), Panchkarma (Shodhan), Sadhvrit (good conduct/ethical regimen for balanced state), Exercise and Diet, Yogic Practices etc. could be effective in the Management of Metabolic Syndrome.
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Context: The concept of epithelial–mesenchymal transition (EMT) in cancer origin, progression, and metastasis is of recent origin and not fully understood. So far, many cell culture studies have been done to investigate the role of EMT in epithelial ovarian cancer, but only a few human studies have been conducted. Aims: The aim of the study is to study the expression of E-cadherin and vimentin in serous and mucinous tumors of the ovary and to compare their expression in benign and malignant serous and mucinous ovarian tumors. Methods: This study was a prospective study done on 60 patients with a histological diagnosis of serous and mucinous ovarian malignancy. The study was conducted in the Department of Pathology and Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. The expression of epithelial marker E-cadherin and mesenchymal marker vimentin was studied in each of the tumors. Statistical Analysis: Unpaired t-test/Mann–Whitney test, Chi-Square test/Fisher's exact test, and Kolmogorov–Smirnov test were used. Results: Of the total 60 cases included in the study, 30 benign and 30 malignant cases of serous and mucinous tumors were taken. Of the 30 benign cases, 22 cases (73.3%) were that of serous cystadenomas, whereas 8 (26.67%) cases were of mucinous cystadenomas. Among the malignant cases, 21 cases (70%) were serous surface epithelial ovarian carcinoma, whereas 9 (30%) were mucinous surface epithelial ovarian carcinoma. Subsequently, the malignant cases were graded according to their glandular differentiation. Immunohistochemistry was performed in each of the 60 cases. Conclusion: In the malignant cases with increasing grade of the tumor, a reduced expression of E-cadherin and an increased expression of vimentin were seen in the epithelial cells
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Production of bioethanol from lignocellulosics can cater to the supply of renewable fuel to transport sector besides being environment friendly. In the present work, bioethanol production potential of Pinus roxburghii needle biomass (PNB) has been studied by optimizing the thermochemical pretreatment method using alkaline conditions (NaOH) firstly by one variable at a time (OVAT) approach, followed by Response Surface Methodology (RSM) with central composite design (CCD) tool. Total reducing sugar (TRS) yield was enhanced from 22.4 g/L (OVAT) to 32.4 g/L using design of experiment (DoE) approach. Effect of pretreatment on PNB was studied by FTIR, phloroglucinol staining and estimation of phenolics which indicated lignin removal. Enzymatic hydrolysis was done by the action of commercial enzymes cellulase and pectinase with loading of 5U/g biomass. The TRS yield was further enhanced to 67.95 g/L after enzymatic hydrolysis. Using separate hydrolysis and cofermentation (SHCF) approach for fermentation of PNB hydrolysate, 28.75 g/L bioethanol was obtained when combined cultures of Saccharomyces cerevisiae (MTCC-36) and Pichia stipitis (NCIM-3498) were used.
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Phytase, as an effective enzyme for phytic acid degradation, has significance in bioremediation, poultry and aquaculture. In view of such an environmental and industrial importance, phytase producing probiotic bacteria have gained attention. Here, we screened lactic acid bacteria (LAB) for their phytase producing potential. The strain showing maximum phytase activity was studied for its probiotic characteristics. Among 20 LAB isolated from Kalarei, an edible source, two isolates K.J (a) and K exhibiting maximum enzyme activity (5.18 U/mL and 5.0 U/mL) were selected. In optimization studies for production of phytase using ‘one-variable-at-a-time’ (OVAT) approach, isolate K showed maximum (5.92 U/mL) enzyme activity. The strain was identified by ribotyping as Lactobacillus paracasei and the sequence was submitted in NCBI GenBank under accession number MK280749. Further optimization studies for phytase production were carried out using Plackett–Burman design and central composite design (CCD) of response surface methodology (RSM). Statistically optimized four significant variables: incubation temperature, initial pH, maltose and peptone resulted in an increase (6.37 U/mL) in enzyme activity. The enzyme was purified 3.97 fold with a specific activity of 278 U/mg.The molecular weight of enzyme was 70 kDa and optimum activity was determined at 37°C, pH 5.5. The strain was designated as Lactobacillus paracasei SMVDUDB1 and showed promising probiotic characteristics viz. survival rate above 80% (low pH, high bile salt concentration under simulated gastrointestinal conditions), hydrophobicity with chloroform (96.74%), autoaggregation (69.61%) and coaggregation ability (82.79%) with Bacillus subtilis.
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Introduction: The women who survive serious complications of pregnancy are referred to as “near miss.” For every maternaldeath, there are many others who suffer serious life-threatening complications of pregnancy, referred to as “near miss” morbidity.In fact, for the over 500,000 mothers who die annually worldwide, and mostly in developing countries, there are more than 8million who suffer severe maternal morbidity (WHO 2004). There is currently no standard definition of “near miss” such as thereis for a maternal death because it is difficult to determine exactly at which point a woman becomes a “near miss.” WHO definesmaternal “near miss” as a woman who nearly died but survived complications that occurred during pregnancy, childbirth, orwithin 42 days of termination of pregnancy.Aims and Objectives: The aim of the study was to determine the magnitude and types of life-threatening maternal complicationsin pregnant and recently delivered women, timing and management, blood transfusion and major surgery, and inpatient durationof stay of patients with “near miss” morbidity.Materials and Methods: The prospective cohort study was done by the Department of Obstetrics and Gynaecology, KamlaRaja Hospital, Gwalior, study period from 1 year, November 2014 to October 2015. Inclusion Criteria: Acute cyanosis, Gasping,Respiratory rate >40 or <6/min, shock, oliguria, clotting failure, loss of consciousness lasting >12 h, stroke, uncontrolled fit/totalparalysis, and jaundice in the presence of pre-eclampsia were included in the study. Exclusion Criteria: Morbidity resulting fromcauses not related to pregnancy or its complication or management, for example, malignancies, ca breast, and liver rupture.Morbidity from accidental or incidental causes no way related to pregnancy, for example, morbidity from automobile accident/suicide. Women who develop these conditions unrelated to pregnancy.Results: Near miss to maternal death ratio as 3.69:1 which means out of five women with severe morbidity we are savingfour cases. Near miss cases are 97 (61%) war multigravida and only 61 (39%) war primigravida. Referred cases were 102to which means 66.1% of near miss were referred to our institute from various center. Only 57 cases (33.9%) came directly.Fifty-four patients (33.9%) have 4 days intensive care unit (ICU) stay followed by 50 cases (31.44%) having 3 days ICU stayand maximum stay was of 6 days in 11 cases.Conclusion: Still, it needs improvement, which can be achieved by ongoing training and simulation sessions for obstetricalstaff in early recognition and management of severe obstetric morbidity and also by resource allocation that is required in themanagement of the near miss cases.
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Disseminated cysticercosis is a rare presentation of human T. Solium infection in which the parasite disseminates via the blood stream throughout the human body. The various clinical manifestations depend upon the location of the parasitic cyst inside the body. Neurocysticercosis is the most common parasite disease of the central nervous system. Disseminated cysticercosis with neurocysticercosis is a very rare presentation of human cysticercus infection. Here we present such a rare case in which a young man presented with multiple swellings all over the body and a history of seizures. Fine needle aspiration cytology was done and the diagnosis was established.
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Background: One of the leading causes of diabetic mortality is cardiovascular disease. Diabetes progression is preceded by pre-diabetic phase which is also at higher cardiovascular risk. Both hyperglycemia and atherosclerotic processes are inflammatory phenomenon. Keeping this in view, it was aimed to evaluate atherogenic indices and correlate them with inflammatory mediators.Methods: This study included 80 controls, 80 pre-diabetic and 80 diabetic patients. Anthropometric parameters (BMI, WHR) and blood parameters like fasting glucose, HbA1c, lipid profile (cholesterol, HDL, LDL TG, VLDL), adiponectin, IL-6, CRP, fibrinogen and uric acid were analysed.Results: Significantly high atherogenic indices were observed in pre-diabetic and diabetic subjects compared to healthy controls. The indices were also significantly correlated with BMI, fasting sugar, HbA1c, cholesterol, HDL, TG and LDL. The correlation with HDL was negative and with other parameters, the correlation was positive. In pre-diabetic patients, adiponectin showed significant negative correlation while fibrinogen and CRP showed significant positive correlation with cardiac risk indices. IL-6 was positively correlated only with AIP while correlation of uric acid with these indices was insignificant. In case of diabetic patients, the cardiac risk indices were significantly correlated with adiponectin, IL-6, CRP, fibrinogen and uric acid. The correlation with adiponectin was negative.Conclusions: The altered atherogenic indices and their significant association with inflammatory markers signify the direct association of inflammation with CVD risks. Thus, there is requirement of novel approaches that can retard inflammatory responses and arrest unwanted cardiac health outcomes.
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The present study was undertaken with the objectives to identify the information-seeking behaviour of women regarding food related health and hygiene practices, and to ascertain the relationship of information-seeking behaviour of women with their personal and socio-economic characteristics. The study was conducted in both the rural and urban areas of Ludhiana district of Punjab, India. A total of 200 women formed the sample for the study, and data was collected with the help of an interview schedule. Information-seeking behaviour was studied in terms of information needs, use of information sources and information source evaluation. Findings of the study revealed that majority of the respondents had low information needs for selected food related health and hygiene practices. Informal sources (like family, friends, neighbours and relatives) were the most frequently used sources of information, whereas use of all information sources i.e. formal sources, informal sources and mass media were found to be low by most of the respondents. Information sources were never evaluated by the majority of the respondents while looking for information on food related health and hygiene practices. Most of the respondents possessed passive information-seeking behaviour for food related health and hygiene practices. Information-seeking behaviour of the respondents was positively correlated with their education, caste, family income and mass media exposure while age of the respondents was negatively correlated with their information-seeking behaviour.
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Diabetes is a metabolic disorder associated with chronic inflammation. It is preceded by pre-diabetic phase that is also influenced with the inflammatory mechanisms which finally culminate into diabetes and its associated complications. Thus the main objective of this study was to assess the level of inflammatory mediators in pre-diabetic and diabetic patients. Methods: This case control study was conducted with 100 controls, 145 pre-diabetic patients and 126 diabetic patients in Santosh medical College and Hospital, Ghaziabad. Serum routine parameters like fasting glucose, HbA1c, lipid and inflammatory mediators like adiponectin, fibrinogen, IL-6, CRP and uric acid were estimated using kit based methods. Results: We observed significantly low adiponectin and significantly high CRP, IL-6, fibrinogen and uric acid in pre-diabetic and diabetic patients compared to controls. The level showed gradual decrease from control-prediabetic-diabetic groups in case of adiponectin while the trend was increasing in case of CRP, IL-6, fibrinogen and uric acid. We also found significant negative correlation of adiponectin with CRP, IL-6, fibrinogen and uric acid in both the patient groups but the correlation with uric acid in pre-diabetic patients was insignificant. Conclusion: These results reveal the involvement of inflammatory mechanisms in progression from normoglycemia to impaired fasting glucose and finally to hyperglycemia. Therefore the development of mechanisms that aid in reducing pro-inflammatory and alleviating ntiinflammatory mediators may be fruitful in reducing diabetes risks.
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Background: Genital tuberculosis is an important cause of female infertility in developing countries like India. It is one of the major causes for severe tubal disease leading to infertility.Methods: A prospective study was conducted in which 100 women presented to hospital with infertility were subjected to hystero-laparoscopy over 1 year. Endometrium sent for tuberculosis polymerase chain reaction (TB-PCR) and HPE and results were formulated.Results: Out of 100 women, 28% were diagnosed with Genital tuberculosis (GTB) using accepted clinical criteria, TB-PCR and endometrial HPE. 25 of these 28 were diagnosed by hysterolaparoscopy (89.24%) alone, 16 by positive endometrial TB-PCR (57.14%) and another 2 by HPE (7.14%).Conclusions: In country like ours where TB is endemic, a multi-pronged approach to diagnosis increases the chances of successfully diagnosing this destructive disease.
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Introduction: Type-2 diabetes mellitus is a common, chronic metabolic disorder with multiple complications if not well controlled. Depression is a very common psychiatric comorbidity in these patients. Multiple environmental and patient related factors are linked with this co-morbidity. It is important to address depression and related factors in these patients for a better outcome. This study aimed to assess depression and distribution of various socio-demographic and clinical details in patients of type-2 diabetes mellitus. Material and Methods: Using a purposive sampling technique, a total of 118 patients of type-2 diabetes mellitus who fulfilled the inclusion and exclusion criteria of this study were enrolled. They were administered Hamilton Depression Rating Scale to assess depression. Overall 66.1% of the patients had co-morbidity of depression. Results: Significantly more number of patients of type-2 diabetes mellitus with co-morbid depression were unmarried (41% vs 15%, χ2=9.029, df=2, p<.05), unemployed/unskilled workers (21.8% vs 5% / 73.1% vs 55%, χ2=24.893, df=2, p<.01), from lower socio-economic status (71.8% vs 52.5%, χ2=4.342, df=1, p<.05), joint family (33.3% vs 7.5%, χ2=9.519, df=1, p<.05) and rural background (82.1% vs 62.5%, χ2=5.453, df=1, p<.05), and had poor control of the level of HbA1c (55.1% vs 2.5%, χ2=41.022, df=2, p<.01) than those without co-morbid depression. There was a significant negative correlation of years in education with HAM-D total score (r=-.471, p<0.01). Conclusion: A co-morbidity of depression is very common in patients of type-2 diabetes mellitus and various sociodemographic and clinical factors are linked to this comorbidity. It is important to address these issues for the sake of overall better outcome in type-2 diabetes mellitus.
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Background: Extracranial head and neck schwannomas are rare tumors which are often clinically misdiagnosed. Preoperative diagnosis of these tumors is challenging but imperative for surgeons so as to avoid nerve damage during excision. Materials and Methods: Sixteen patients diagnosed with extracranial head and neck schwannomas over a period of 2 years were retrospectively analyzed. Clinical details including preoperative fine-needle aspiration cytology (FNAC) and/or computed tomography (CT)/magnetic resonance imaging (MRI) findings were retrieved. FNAC smears and formalin-fixed paraffin-embedded sections were evaluated. Results: Among these 16 tumors, 6 (37.5%) were located in the lateral aspect of neck, 4 (25%) in scalp, 2 (12.5%) in orbit, and one each (6.25%) in palate, tongue, submandibular gland and parotid gland. The mean patient age was 31.3 years. FNAC was performed in 14 cases, of which 8 cases (58.3%) showed features of benign nerve sheath tumor (BNST), two cases (14.2%) were inconclusive with possibility of mesenchymal lesion, two cases (14.2%) were inadequate, one case (8.3%) showed features suggestive of schwannoma, and a diagnosis of nerve sheath tumor inconclusive for malignancy was rendered in a single case. The sensitivity of FNAC in diagnosis of BNST was 71.4%. CT or MRI was performed in five cases, of which an accurate diagnosis was rendered only in one case of orbital schwannoma. Conclusion: Imaging has a limited role in the preoperative diagnosis of head and neck schwannomas owing to nonspecific radiological features. Cellular aspirate smears are helpful in accurate diagnosis even at unusual locations
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Background: The most fundamental trait of cancer cells involves their ability to sustain chronic proliferation. Tumors have a complex cellular ecology that establishes the malignant potential of the tumor. In these ecosystems, innate immune cells are highly represented. Many contradictory reports have been published regarding the impact of tumor-infiltrating immune cells on proliferation of the tumors. Aim: This study aims to assess the impact of CD45RO+ve immune cells on proliferation and dedifferentiation of node-negative squamous cell carcinomas of cheek mucosa (SCC-CM). Materials and Methods: Thirty formalin-fixed paraffin-embedded tissue blocks of previously diagnosed node-negative SCC-CM subclassified as Grade I SCC – 10 cases; Grade II SCC – 10 cases; and Grade III SCC – 10 cases (Broders' classification – 1927). Immunohistochemistry performed on each selected tissue section using anti-p53 and anti-CD45RO as primary antibodies. Semi-quantitative analyses performed for all the tissue sections to assess the p53 and CD45RO expression. p53:CD45RO expression ratio calculated. The data were statistically analyzed using GraphPad Prism 5 for Windows. Results: Our results showed statistically significant increase (P = 0.0006) in p53 expression and decrease (P = 0.0044) in CD45RO+ immune cell response with the decrease in differentiation of SCC-CMs using Fisher's exact test and statistically significant increase (P < 0.001) in p53:CD45RO expression ratio with decrease in differentiation using one-way ANOVA. Conclusion: Based on all these findings from the present study, we perceive the following findings. In node-negative SCC-CMs, CD45RO+ immune cells play a possible role in controlling the dedifferentiation of the tumor and in limiting the proliferative potential of the tumor cells which are tumor antagonistic in nature
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Background: Aim of the study was to evaluate the role of NST (labour admission test) as a screening method in management of low risk pregnancies and to study the correlation of NST with fetal outcome.Methods: A prospective observational study conducted over 500 patients managed at our centre after proper evaluation. Patients were evaluated for mode of delivery and neonatal outcome.Results: The maximum number 352 of patients belonged to 20-30 years age group, 113 patients belonged to 31-35 age group. 200 patients were of 37-40 weeks gestation and 185 were of 40-41 weeks gestation. There were 125 patients in the 41-42 weeks gestational period. Among the 500 pregnant mothers who were included in the study 82.6% had Normal NST, 11.6% had suspicious and 5.8% had pathological NST. Cesarean rate was 14.4% in normal NST group, 58.62% in suspicious group and 72.41% in pathological group study. 6.77% in Normal group had meconium stained liquor at delivery whereas 29.31% in suspicious group and 37.93% in pathological group had same.Conclusions: The non-stress test is an important screening tool to identity the fetus in jeopardy in utero. This enables an appropriate timely intervention to achieve the most favorable outcome.
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The unhealthy effects of indoor air pollution by cooking fuels is great concern for good respiratory health. Present study was conducted to study and compare the effects of two major fuels used in developing countries like India, Kerosene and Liquefied Petroleum Gas (LPG) in rural women of Amritsar, India. Methods: Study was conducted on 800 rural women out of which 400 using Kerosene as cooking fuel and rest 400 using LPG. Subjects of chronic and recent respiratory illness even if treated were excluded Ventilatory functions of lungs were done on computerized spirometer, MED-SPIRER. Results: There was statistically significant decline in FEV1 in Kerosene using women (0.98±0.47) when compared with LPG using women (1.86±0.37). Other parameters FEV3, PEFR, FEF 25-75%, FEF2-12, FEF 25%, FEF 50% FEF 75% and MVV showed similar significant decline in women using Kerosene as fuel. Conclusion: There is significant decline in ventilator function od lungs in women using Kerosene as cooking fuel, which is still used in developing country like India. Reduced values indicate small airway obstruction.
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Postpartum iron deficiency anaemia (IDA) is common in women in resource-poor countries. Most women are treated with either oral iron or blood transfusion. The aim of our study was to find out the prevalence of postpartum anemia; and to compare the effect of treatment with either oral ferrous sulphate or intravenous iron sucrose on postpartum IDA. Methods: 102 postpartum women with proven iron deficiency anemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg , two to three doses given on alternate days (group 2). Total iron deficit was calculated using standard formula and results analyzed. Main outcome measures: Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartum. Result: The prevalence of postpartum anaemia was 19.92%. By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81± 0.849 to 9.88± 0.760 gm/dl which was more than those treated with oral iron (p<0.0001); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.0001). Conclusion: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly.
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Background: There is increasing concern that vitamin D deficiency may play etiological role in Febrile seizures. Few studies have reported vitamin D deficiency in children with recurrent febrile seizures and hypocalcemia seizures. 'The objective of this study is to explore vitamin D status in children aged 6 months to 5 years with first episode of febrile seizure and to find the association between vitamin D levels and febrile seizure.Methods: A hospital-based case control study was conducted in sub district hospital, Katra over a period of three years. Cases were children of age group 6 months to 5 years presenting with first episode of simple febrile seizure to the casualty or OPD. For each case, a control was selected with similar age group and same sex who came for short duration fever (<2 days) but without seizures. A 5ml of blood sample for measurement of 25 hydroxy vitamin D was taken from the peripheral vein of each participant by trained laboratory technician. In order to categorise various degrees of vitamin D deficiency, Indian Academy of paediatrics criteria was used. Results were presented in the form of percentages and Odds ratio was calculated as measure of association.Results: A total of 75 cases and 75 controls were included in the study. Cases and controls were comparable as per baseline characteristics. Strong and significant (p<0.01) association of febrile seizures with vit D levels was observed.Conclusions: There was a high prevalence of vitamin D insufficiency among cases of simple febrile seizure.